Reactome | B3GAT dimers transfer GlcA to tetrasaccharide linker

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B3GAT dimers transfer GlcA to tetrasaccharide linker Show undefined attributes

authored	[InstanceEdit:1889961] Jassal, B, 2011-11-01
catalystActivity	[CatalystActivity:1889977] galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity of B3GAT dimers [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:1889961] Jassal, B, 2011-11-01
dbId	1889955
displayName	B3GAT dimers transfer GlcA to tetrasaccharide linker
edited	[InstanceEdit:1889961] Jassal, B, 2011-11-01
eventOf	[Pathway:R-HSA-1971475] A tetrasaccharide linker sequence is required for GAG synthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-1971482] The addition of GalNAc to the terminal glucuronate residue forms chondroitin - Homo sapiens [Reaction:R-HSA-2022919] EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue - Homo sapiens
input	[DefinedSet:R-HSA-2064214] Gal-Gal-Xyl-proteins [Golgi lumen] [SimpleEntity:R-ALL-1889970] UDP-GlcA [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1889979] Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1 [LiteratureReference:1889974] Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans [LiteratureReference:1889986] Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues [LiteratureReference:1889985] Cloning, characterization, and chromosome mapping of the human GlcAT-S gene
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	B3GAT dimers transfer GlcA to tetrasaccharide linker A glucuronate moiety is the fourth addition to the tetrasaccharide linker
orthologousEvent	[Reaction:R-CEL-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Caenorhabditis elegans [Reaction:R-DME-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Drosophila melanogaster [Reaction:R-GGA-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Gallus gallus [Reaction:R-XTR-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Xenopus tropicalis [Reaction:R-DRE-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Danio rerio [Reaction:R-SSC-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Sus scrofa [Reaction:R-BTA-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Bos taurus [Reaction:R-CFA-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Canis familiaris [Reaction:R-RNO-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Rattus norvegicus [Reaction:R-MMU-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Mus musculus
output	[DefinedSet:R-HSA-2064225] GlcA-Gal-Gal-Xyl-proteins [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1889955
summation	[Summation:1889959] B3GAT1 (Kitagawa et al. 1998) and B3GAT2 (Marcos et al. 2002...

Referrals

(precedingEvent)	[Reaction:R-HSA-1971482] The addition of GalNAc to the terminal glucuronate residue forms chondroitin [Reaction:R-HSA-2022919] EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue
(hasEvent)	[Pathway:R-HSA-1971475] A tetrasaccharide linker sequence is required for GAG synthesis

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