Reactome | FAM20B phosphorylates Xyl moiety

Schema > Reaction > Entries

FAM20B phosphorylates Xyl moiety Show undefined attributes

authored	[InstanceEdit:9941287] Stephan, Ralf, 2025-02-15
catalystActivity	[CatalystActivity:9941295] phosphotransferase activity, alcohol group as acceptor of FAM20B [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen
created	[InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
crossReference	[DatabaseIdentifier:9941335] RHEA:19462
dbId	9941039
displayName	FAM20B phosphorylates Xyl moiety
edited	[InstanceEdit:9948077] Stephan, Ralf, 2025-05-15
eventOf	[Pathway:R-HSA-1971475] Glycosaminoglycan-protein linkage region biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-9940993] PXYLP1 dephosphorylates Xyl moiety - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:5433358] negative regulation of proteoglycan biosynthetic process
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-2064225] GlcA-Gal-Gal-Xyl-proteins [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9941037] FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region [LiteratureReference:9941222] Chondroitin sulfate metabolism in the brain
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	FAM20B phosphorylates Xyl moiety
negativePrecedingEvent	[NegativePrecedingEvent:9941299] Futile Cycle: PXYLP1 dephosphorylates Xyl moiety
orthologousEvent	[Reaction:R-BTA-9941039] FAM20B phosphorylates Xyl moiety - Bos taurus [Reaction:R-DME-9941039] FAM20B phosphorylates Xyl moiety - Drosophila melanogaster [Reaction:R-GGA-9941039] FAM20B phosphorylates Xyl moiety - Gallus gallus [Reaction:R-XTR-9941039] FAM20B phosphorylates Xyl moiety - Xenopus tropicalis [Reaction:R-DRE-9941039] FAM20B phosphorylates Xyl moiety - Danio rerio [Reaction:R-SSC-9941039] FAM20B phosphorylates Xyl moiety - Sus scrofa [Reaction:R-CFA-9941039] FAM20B phosphorylates Xyl moiety - Canis familiaris [Reaction:R-RNO-9941039] FAM20B phosphorylates Xyl moiety - Rattus norvegicus [Reaction:R-MMU-9941039] FAM20B phosphorylates Xyl moiety - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-9941158] GlcA-Gal-Gal-XylP-proteins [Golgi lumen] [SimpleEntity:R-ALL-425969] H+ [Golgi lumen]
precedingEvent	[Reaction:R-HSA-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9948076] D'Eustachio, Peter, 2025-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9941039
summation	[Summation:9941048] Glycosaminoglycan xylosylkinase FAM20B phosphorylates the xy...

Referrals

(hasEvent)	[Pathway:R-HSA-1971475] Glycosaminoglycan-protein linkage region biosynthesis
(precedingEvent)	[Reaction:R-HSA-9940993] PXYLP1 dephosphorylates Xyl moiety