Expression of FGFR1OP-FGFR1 in both Ba/F3 and Cos-1 cells leads to phosphorylation of STAT1 and STAT3 but not STAT5, and to activation of a STAT1/3-responsive reporter when expressed in NIH3T3 cells (Guasch, 2001). Activation of STAT proteins has also been shown to be oncogenic in the context of derivatives of FGFR1, 3 and 4 that lack the extracellular domain and are are targetted to the plasma membrane by a myristylation signal (Hart et al, 2000).
Borg, JP, Guasch, G, Birnbaum, D, Pébusque, MJ, Ollendorff, V
Tynan, JA, Donoghue, DJ, Hart, KC, Kanemitsu, MY, Robertson, SC, Meyer, AN
protein tyrosine kinase activity of FGFR1OP-p-FGFR1 fusion mutant dimer [cytosol]
Gain of function of FGFR1OP-p-FGFR1 fusion mutant dimer [cytosol]
© 2022 Reactome
