FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Expression of FGFR1OP-FGFR1 in both Ba/F3 and Cos-1 cells leads to phosphorylation of STAT1 and STAT3 but not STAT5, and to activation of a STAT1/3-responsive reporter when expressed in NIH3T3 cells (Guasch, 2001). Activation of STAT proteins has also been shown to be oncogenic in the context of derivatives of FGFR1, 3 and 4 that lack the extracellular domain and are are targetted to the plasma membrane by a myristylation signal (Hart et al, 2000).

Literature References
PubMed ID Title Journal Year
11689702 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways

Borg, JP, Guasch, G, Birnbaum, D, P├ębusque, MJ, Ollendorff, V

Mol Cell Biol 2001
10918587 Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

Tynan, JA, Donoghue, DJ, Hart, KC, Kanemitsu, MY, Robertson, SC, Meyer, AN

Oncogene 2000
Catalyst Activity

protein tyrosine kinase activity of FGFR1OP-p-FGFR1 fusion mutant dimer [cytosol]

Functional status

Gain of function of FGFR1OP-p-FGFR1 fusion mutant dimer [cytosol]

Disease Entity
Name Identifier Synonyms
subacute leukemia DOID:3264
precursor lymphoblastic lymphoma/leukemia DOID:5600
myelodysplastic myeloproliferative cancer DOID:4972 Myeloproliferative/Myelodysplastic syndromes, unclassifiable myelodysplastic myeloproliferative disease, Unclassifiable Myeloproliferative/Myelodysplastic syndrome, Myelodysplastic/myeloproliferative disease (morphologic abnormality)
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cite Us!