Reactome | Engulfed CpG DNA binds to endosomal C-ter TLR9

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Engulfed CpG DNA binds to endosomal C-ter TLR9 Show undefined attributes

category	binding
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:187896] de Bono, B, 2006-09-28 16:38:50
dbId	187895
displayName	Engulfed CpG DNA binds to endosomal C-ter TLR9
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-168138] Toll Like Receptor 9 (TLR9) Cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-188002] Rab5-mediated recruitment of class III PI3K to TLR9 - Homo sapiens [Reaction:R-HSA-975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9 - Homo sapiens
input	[Complex:R-HSA-1679581] C-ter-TLR9 dimer [endosome membrane] [OtherEntity:R-ALL-167913] Unmethylated CpG DNA [endosome membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:188077] The immunobiology of the TLR9 subfamily [LiteratureReference:1679551] Negative regulation of signaling by a soluble form of toll-like receptor 9
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Engulfed CpG DNA binds to endosomal C-ter TLR9
orthologousEvent	[Reaction:R-SSC-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - Sus scrofa [Reaction:R-BTA-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - Bos taurus [Reaction:R-CFA-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - Canis familiaris [Reaction:R-RNO-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - Rattus norvegicus [Reaction:R-MMU-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - Mus musculus
output	[Complex:R-HSA-1679087] C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane]
precedingEvent	[Reaction:R-HSA-1678920] TLR processing at low pH - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-187892] Positive regulation by 'EEA1:EEA1 [endosome membrane]' [NegativeRegulation:9691209] Negative regulation by 'C-ter TLR9 dimer:HCQ [endosome membrane]'
regulationReference	[RegulationReference:9641830] Positive regulation by 'EEA1:EEA1 [endosome membrane]' TLR signaling [RegulationReference:9691208] Negative regulation by 'C-ter TLR9 dimer:HCQ [endosome membrane]' Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-187895
summation	[Summation:188746] Synthetic oligodeoxynucleotides (ODN) expressing non-methyla...
updateTrackers	[UpdateTracker:9788333] Update Tracker - [Reaction:187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - v42:[addLiteratureReference] [UpdateTracker:9789070] Update Tracker - [Reaction:187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - v39:[add_removeInput, add_removeOutput] [UpdateTracker:9789943] Update Tracker - [Reaction:187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - v36:[add_removeInput] [UpdateTracker:9776854] Update Tracker - [Reaction:187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - v74:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9788333] Update Tracker - [Reaction:187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - v42:[addLiteratureReference] [UpdateTracker:9789070] Update Tracker - [Reaction:187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - v39:[add_removeInput, add_removeOutput] [UpdateTracker:9789943] Update Tracker - [Reaction:187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - v36:[add_removeInput] [UpdateTracker:9776854] Update Tracker - [Reaction:187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - v74:[addRegulator]
(hasEvent)	[Pathway:R-HSA-168138] Toll Like Receptor 9 (TLR9) Cascade
(precedingEvent)	[Reaction:R-HSA-188002] Rab5-mediated recruitment of class III PI3K to TLR9 [Reaction:R-HSA-975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9

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