Reactome | TLR processing at low pH

Schema > Reaction > Entries

TLR processing at low pH Show undefined attributes

authored	[InstanceEdit:1679075] Shamovsky, V, 2011-10-19
catalystActivity	[CatalystActivity:1678966] cysteine-type endopeptidase activity of Legumain/Cathepsins [endolysosome lumen]
category	transition
compartment	[Compartment:1660541] endolysosome membrane
created	[InstanceEdit:1679075] Shamovsky, V, 2011-10-19
dbId	1678920
displayName	TLR processing at low pH
edited	[InstanceEdit:2129343] Shamovsky, V, 2012-02-19
eventOf	[Pathway:R-HSA-1679131] Trafficking and processing of endosomal TLR - Homo sapiens
followingEvent	[Reaction:R-HSA-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - Homo sapiens
input	[Complex:R-HSA-188168] FL-TLR7 dimer [endolysosome membrane] [Complex:R-HSA-1679073] FL-TLR9 dimer [endolysosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1679562] Cathepsins are required for Toll-like receptor 9 responses [LiteratureReference:1678987] Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase [LiteratureReference:1679556] Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9 [LiteratureReference:1679134] The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	TLR processing at low pH
orthologousEvent	[Reaction:R-SSC-1678920] TLR processing at low pH - Sus scrofa [Reaction:R-BTA-1678920] TLR processing at low pH - Bos taurus [Reaction:R-CFA-1678920] TLR processing at low pH - Canis familiaris [Reaction:R-RNO-1678920] TLR processing at low pH - Rattus norvegicus [Reaction:R-MMU-1678920] TLR processing at low pH - Mus musculus
output	[Complex:R-HSA-1678924] C-ter TLR7 dimer [endolysosome membrane] [Complex:R-HSA-1678956] C-ter-TLR9 dimer [endolysosome membrane]
precedingEvent	[BlackBoxEvent:R-HSA-1678927] UNC93B1 delivers endosomal full-length TLRs to endolysosome - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-2134525] Positive regulation by 'H+ [endolysosome lumen]'
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121211] Gillespie, ME, 2012-02-09 [InstanceEdit:2153487] Leifer, CA, Rose II, WA, 2012-02-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1678920
summation	[Summation:1679553] Endosome maturation (acidification) is required for both the...
updateTrackers	[UpdateTracker:9778609] Update Tracker - [Reaction:1678920] TLR processing at low pH - v68:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9778609] Update Tracker - [Reaction:1678920] TLR processing at low pH - v68:[add_removeRegulator]
(hasEvent)	[Pathway:R-HSA-1679131] Trafficking and processing of endosomal TLR
(precedingEvent)	[Reaction:R-HSA-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9