Reactome | C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane]

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C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] Show undefined attributes

compartment	[Compartment:74700] endosome membrane
consumedByEvent	[Reaction:R-HSA-188002] Rab5-mediated recruitment of class III PI3K to TLR9 - Homo sapiens
created	[InstanceEdit:1679091] Shamovsky, V, 2011-10-19
dbId	1679087
displayName	C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane]
hasComponent	[Complex:R-HSA-1679581] C-ter-TLR9 dimer [endosome membrane] [OtherEntity:R-ALL-167913] Unmethylated CpG DNA [endosome membrane]
inDisease	false
inferredTo	[Complex:R-MMU-1679087] C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] - Mus musculus [Complex:R-RNO-1679087] C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] - Rattus norvegicus [Complex:R-CFA-1679087] C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] - Canis familiaris [Complex:R-BTA-1679087] C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] - Bos taurus [Complex:R-SSC-1679087] C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] - Sus scrofa
literatureReference	[LiteratureReference:1679106] Homology modeling of human Toll-like receptors TLR7, 8, and 9 ligand-binding domains [LiteratureReference:2445194] Single molecule in vivo analysis of toll-like receptor 9 and CpG DNA interaction [LiteratureReference:1679137] TLR9 signals after translocating from the ER to CpG DNA in the lysosome [LiteratureReference:1679563] TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA [LiteratureReference:1679551] Negative regulation of signaling by a soluble form of toll-like receptor 9
maxDepth	3
memberOf	[DefinedSet:R-HSA-975158] Activated TLR7-9 homodimers [endosome membrane] - Homo sapiens
modified	[InstanceEdit:2445241] Shamovsky, V, 2012-08-13
name	C-ter TLR9 dimer:unmethylated CpG DNA
producedByEvent	[Reaction:R-HSA-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1679087
updateTrackers	[UpdateTracker:9873324] Update Tracker - [Complex:1679087] C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9873324] Update Tracker - [Complex:1679087] C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
(input)	[Reaction:R-HSA-188002] Rab5-mediated recruitment of class III PI3K to TLR9
(output)	[Reaction:R-HSA-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9
(hasMember)	[DefinedSet:R-HSA-975158] Activated TLR7-9 homodimers [endosome membrane]

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