Engulfed CpG DNA binds to endosomal C-ter TLR9

Stable Identifier
R-HSA-187895
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endosome membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Engulfed CpG DNA binds to endosomal C-ter TLR9
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Synthetic oligodeoxynucleotides (ODN) expressing non-methylated CpG motifs patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern by TLR9, and triggers a rapid innate immune response.
Literature References
PubMed ID Title Journal Year
15207506 The immunobiology of the TLR9 subfamily

Wagner, H

Trends Immunol 2004
21604257 Negative regulation of signaling by a soluble form of toll-like receptor 9

Cameron, JL, Brooks, JC, Chockalingam, A, Leifer, CA

Eur J Immunol 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
C-ter TLR9 dimer:HCQ [endosome membrane] (Homo sapiens)
Positively by
Regulator
EEA1:EEA1 [endosome membrane] (Homo sapiens)
Orthologous Events
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Bos taurus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Canis familiaris)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Mus musculus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Rattus norvegicus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Sus scrofa)
Created
de Bono, B  (2006-09-28)
Cite Us!