Engulfed CpG DNA binds to endosomal C-ter TLR9

Stable Identifier
R-HSA-187895
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endosome membrane
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Engulfed CpG DNA binds to endosomal C-ter TLR9
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Synthetic oligodeoxynucleotides (ODN) expressing non-methylated CpG motifs patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern by TLR9, and triggers a rapid innate immune response.

Literature References
PubMed ID Title Journal Year
21604257 Negative regulation of signaling by a soluble form of toll-like receptor 9

Chockalingam, A, Cameron, JL, Brooks, JC, Leifer, CA

Eur J Immunol 2011
15207506 The immunobiology of the TLR9 subfamily

Wagner, H

Trends Immunol 2004
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Orthologous Events
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Created
de Bono, B  (2006-09-28)
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