Reactome | PLC-gamma binds to the active receptor

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PLC-gamma binds to the active receptor Show undefined attributes

authored	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:186802] Jassal, B, 2006-08-15 13:51:10
dbId	186765
displayName	PLC-gamma binds to the active receptor
edited	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
eventOf	[Pathway:R-HSA-186763] Downstream signal transduction - Homo sapiens
followingEvent	[Reaction:R-HSA-1524186] Phosphorylation of PLCgamma by PDGFR - Homo sapiens
input	[Complex:R-HSA-186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-167682] PLCG1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:381858] Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma [LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors [LiteratureReference:382010] Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PLC-gamma binds to the active receptor
negativePrecedingEvent	[NegativePrecedingEvent:9865974] Futile Cycle: Activated PLC gamma dissociates from the PDGF receptor
orthologousEvent	[Reaction:R-CEL-186765] PLC-gamma binds to the active receptor - Caenorhabditis elegans [Reaction:R-DME-186765] PLC-gamma binds to the active receptor - Drosophila melanogaster [Reaction:R-GGA-186765] PLC-gamma binds to the active receptor - Gallus gallus [Reaction:R-XTR-186765] PLC-gamma binds to the active receptor - Xenopus tropicalis [Reaction:R-DRE-186765] PLC-gamma binds to the active receptor - Danio rerio [Reaction:R-SSC-186765] PLC-gamma binds to the active receptor - Sus scrofa [Reaction:R-BTA-186765] PLC-gamma binds to the active receptor - Bos taurus [Reaction:R-CFA-186765] PLC-gamma binds to the active receptor - Canis familiaris [Reaction:R-RNO-186765] PLC-gamma binds to the active receptor - Rattus norvegicus [Reaction:R-MMU-186765] PLC-gamma binds to the active receptor - Mus musculus
output	[Complex:R-HSA-186795] PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane]
precedingEvent	[Reaction:R-HSA-186786] Autophosphorylation of PDGF beta receptors - Homo sapiens [Reaction:R-HSA-389083] Autophosphorylation of PDGF alpha receptors - Homo sapiens [Reaction:R-HSA-389086] Autophosphorylation of PDGF alpha/beta receptors - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:382617] Heldin, CH, 2008-11-23 19:29:34
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-186765
summation	[Summation:186840] PLC-gamma 1 has been shown to bind to phosphorylated Tyr 102...
updateTrackers	[UpdateTracker:9787420] Update Tracker - [Reaction:186765] PLC-gamma binds to the active receptor - v45:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9787420] Update Tracker - [Reaction:186765] PLC-gamma binds to the active receptor - v45:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-186763] Downstream signal transduction
(precedingEvent)	[Reaction:R-HSA-1524186] Phosphorylation of PLCgamma by PDGFR

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