Reactome | Downstream signal transduction

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Downstream signal transduction Show undefined attributes

authored	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
created	[InstanceEdit:186802] Jassal, B, 2006-08-15 13:51:10
crossReference	[DatabaseIdentifier:12819479] BioModels Database:BIOMD0000000288
dbId	186763
displayName	Downstream signal transduction
edited	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
eventOf	[Pathway:R-HSA-186797] Signaling by PDGF - Homo sapiens
figure	[Figure:382625] /figures/PDGF_interactions.jpg
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-186780] PI3-kinase binds to the active receptor - Homo sapiens [Reaction:R-HSA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-186765] PLC-gamma binds to the active receptor - Homo sapiens [Reaction:R-HSA-1524186] Phosphorylation of PLCgamma by PDGFR - Homo sapiens [Reaction:R-HSA-1524182] Activated PLC gamma dissociates from the PDGF receptor - Homo sapiens [Reaction:R-HSA-186819] SH2 domain of Src binds to the active receptor - Homo sapiens [Reaction:R-HSA-380780] Activation of Src - Homo sapiens [Reaction:R-HSA-186778] SHP2 binds to the active receptor - Homo sapiens [Reaction:R-HSA-186798] GAP binds to PDGF-beta receptors only - Homo sapiens [Reaction:R-HSA-186826] GRB2:SOS1 complex binds to the active receptor - Homo sapiens [Reaction:R-HSA-186834] SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) - Homo sapiens [Reaction:R-HSA-380782] STAT binds to the active receptor - Homo sapiens [Reaction:R-HSA-382056] Crk binds to the active PDGF receptor - Homo sapiens [Reaction:R-HSA-382052] p130Cas and C3G bind PDGFR bound Crk - Homo sapiens [Reaction:R-HSA-382058] Nck binds to the active PDGF receptor - Homo sapiens [Reaction:R-HSA-382055] Grb7 binds to the active PDGF receptor - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:380730] Mechanism of action and in vivo role of platelet-derived growth factor [LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Downstream signal transduction
orthologousEvent	[Pathway:R-MMU-186763] Downstream signal transduction - Mus musculus [Pathway:R-RNO-186763] Downstream signal transduction - Rattus norvegicus [Pathway:R-CFA-186763] Downstream signal transduction - Canis familiaris [Pathway:R-BTA-186763] Downstream signal transduction - Bos taurus [Pathway:R-SSC-186763] Downstream signal transduction - Sus scrofa [Pathway:R-DRE-186763] Downstream signal transduction - Danio rerio [Pathway:R-XTR-186763] Downstream signal transduction - Xenopus tropicalis [Pathway:R-GGA-186763] Downstream signal transduction - Gallus gallus [Pathway:R-CEL-186763] Downstream signal transduction - Caenorhabditis elegans [Pathway:R-DME-186763] Downstream signal transduction - Drosophila melanogaster
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:382617] Heldin, CH, 2008-11-23 19:29:34
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-186763
summation	[Summation:186815] The role of autophosphorylation sites on PDGF receptors are ...
updateTrackers	[UpdateTracker:9780813] Update Tracker - [Pathway:186763] Downstream signal transduction - v62:[removeHasEvent] [UpdateTracker:9784172] Update Tracker - [Pathway:186763] Downstream signal transduction - v54:[updateIndirectRLE] [UpdateTracker:9788459] Update Tracker - [Pathway:186763] Downstream signal transduction - v42:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783898] Update Tracker - [Pathway:186763] Downstream signal transduction - v55:[updateIndirectRLE] [UpdateTracker:9789365] Update Tracker - [Pathway:186763] Downstream signal transduction - v38:[add_removeHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791004] Update Tracker - [Pathway:186763] Downstream signal transduction - v32:[updateContainedRLE] [UpdateTracker:9782962] Update Tracker - [Pathway:186763] Downstream signal transduction - v58:[updateContainedPathway] [UpdateTracker:9783611] Update Tracker - [Pathway:186763] Downstream signal transduction - v56:[updateContainedPathway] [UpdateTracker:9788969] Update Tracker - [Pathway:186763] Downstream signal transduction - v39:[updateIndirectRLE] [UpdateTracker:9779834] Update Tracker - [Pathway:186763] Downstream signal transduction - v64:[updateContainedRLE] [UpdateTracker:9784806] Update Tracker - [Pathway:186763] Downstream signal transduction - v53:[add_removeHasEvent] [UpdateTracker:9781306] Update Tracker - [Pathway:186763] Downstream signal transduction - v61:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9787977] Update Tracker - [Pathway:186763] Downstream signal transduction - v44:[updateContainedRLE] [UpdateTracker:9779256] Update Tracker - [Pathway:186763] Downstream signal transduction - v66:[updateContainedRLE] [UpdateTracker:9775209] Update Tracker - [Pathway:186763] Downstream signal transduction - v80:[updateContainedRLE] [UpdateTracker:9785403] Update Tracker - [Pathway:186763] Downstream signal transduction - v52:[updateIndirectRLE] [UpdateTracker:9777219] Update Tracker - [Pathway:186763] Downstream signal transduction - v72:[updateContainedRLE] [UpdateTracker:9786668] Update Tracker - [Pathway:186763] Downstream signal transduction - v49:[updateContainedPathway] [UpdateTracker:9782210] Update Tracker - [Pathway:186763] Downstream signal transduction - v59:[updateIndirectRLE] [UpdateTracker:9787492] Update Tracker - [Pathway:186763] Downstream signal transduction - v45:[updateContainedRLE]

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[Pathway:R-HSA-186797] Signaling by PDGF

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