Reactome | PDGF:Phospho-PDGF receptor dimer [plasma membrane]

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PDGF:Phospho-PDGF receptor dimer [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-380766] PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] - Homo sapiens [Complex:R-HSA-186839] PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-186778] SHP2 binds to the active receptor - Homo sapiens [Reaction:R-HSA-382055] Grb7 binds to the active PDGF receptor - Homo sapiens [Reaction:R-HSA-382056] Crk binds to the active PDGF receptor - Homo sapiens [Reaction:R-HSA-382058] Nck binds to the active PDGF receptor - Homo sapiens [Reaction:R-HSA-186819] SH2 domain of Src binds to the active receptor - Homo sapiens [Reaction:R-HSA-186780] PI3-kinase binds to the active receptor - Homo sapiens [Reaction:R-HSA-186765] PLC-gamma binds to the active receptor - Homo sapiens [Reaction:R-HSA-186826] GRB2:SOS1 complex binds to the active receptor - Homo sapiens [Reaction:R-HSA-380782] STAT binds to the active receptor - Homo sapiens
created	[InstanceEdit:186802] Jassal, B, 2006-08-15 13:51:10
dbId	186811
displayName	PDGF:Phospho-PDGF receptor dimer [plasma membrane]
hasComponent	[DefinedSet:R-HSA-380760] Active PDGF dimers (AA, AB, BB) [extracellular region] [DefinedSet:R-HSA-186821] Phospho- PDGF receptor dimer [plasma membrane]
inDisease	false
includedLocation	[Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - Mus musculus [Complex:R-RNO-186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - Rattus norvegicus [Complex:R-CFA-186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - Canis familiaris [Complex:R-BTA-186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - Bos taurus [Complex:R-SSC-186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - Sus scrofa [Complex:R-DRE-186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - Danio rerio [Complex:R-XTR-186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - Gallus gallus [Complex:R-DME-186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - Caenorhabditis elegans
maxDepth	5
modified	[InstanceEdit:380763] Garapati, P V, 2008-11-14 10:45:00
name	PDGF:Phospho-PDGF receptor dimer
producedByEvent	[Reaction:R-HSA-1524182] Activated PLC gamma dissociates from the PDGF receptor - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-186811
updateTrackers	[UpdateTracker:9894602] Update Tracker - [Complex:186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - v57:[updateContainedComponent] [UpdateTracker:9869048] Update Tracker - [Complex:186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - v32:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9894602] Update Tracker - [Complex:186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - v57:[updateContainedComponent] [UpdateTracker:9869048] Update Tracker - [Complex:186811] PDGF:Phospho-PDGF receptor dimer [plasma membrane] - v32:[updateContainedComponent]
(normalEntity)	[EntityFunctionalStatus:9672149] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane] [EntityFunctionalStatus:9672151] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane] [EntityFunctionalStatus:9672150] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane]
(hasComponent)	[Complex:R-HSA-186839] PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] [Complex:R-HSA-381956] PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] [Complex:R-HSA-380766] PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] [Complex:R-HSA-381955] PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] [Complex:R-HSA-381954] PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] [Complex:R-HSA-186831] PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] [Complex:R-HSA-186795] PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] [Complex:R-HSA-1524184] PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] [Complex:R-HSA-186827] PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] [Complex:R-HSA-186789] PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane]
(input)	[Reaction:R-HSA-186778] SHP2 binds to the active receptor [Reaction:R-HSA-382055] Grb7 binds to the active PDGF receptor [Reaction:R-HSA-380782] STAT binds to the active receptor [Reaction:R-HSA-382056] Crk binds to the active PDGF receptor [Reaction:R-HSA-382058] Nck binds to the active PDGF receptor [Reaction:R-HSA-186819] SH2 domain of Src binds to the active receptor [Reaction:R-HSA-186780] PI3-kinase binds to the active receptor [Reaction:R-HSA-186765] PLC-gamma binds to the active receptor [Reaction:R-HSA-186826] GRB2:SOS1 complex binds to the active receptor
(output)	[Reaction:R-HSA-1524182] Activated PLC gamma dissociates from the PDGF receptor

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