Reactome | I(1,4,5)P3 transports from the cytosol to the nucleus

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I(1,4,5)P3 transports from the cytosol to the nucleus Show undefined attributes

authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:9954155] narrow pore channel activity of Nuclear Pore Complex (NPC) [nuclear envelope]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
dbId	1855190
displayName	I(1,4,5)P3 transports from the cytosol to the nucleus
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf	[Pathway:R-HSA-1855196] IP3 and IP4 transport between cytosol and nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-1855233] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160267] import into nucleus
input	[SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1889856] The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells [LiteratureReference:1889919] The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	I(1,4,5)P3 transports from the cytosol to the nucleus
orthologousEvent	[Reaction:R-SPO-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Schizosaccharomyces pombe [Reaction:R-CEL-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Caenorhabditis elegans [Reaction:R-DME-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Drosophila melanogaster [Reaction:R-GGA-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Gallus gallus [Reaction:R-XTR-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Xenopus tropicalis [Reaction:R-DRE-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Danio rerio [Reaction:R-SSC-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Sus scrofa [Reaction:R-BTA-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Bos taurus [Reaction:R-CFA-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Canis familiaris [Reaction:R-RNO-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Rattus norvegicus [Reaction:R-MMU-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Mus musculus
output	[SimpleEntity:R-ALL-2023907] I(1,4,5)P3 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane - Homo sapiens [Reaction:R-HSA-1855205] I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol - Homo sapiens [Reaction:R-HSA-1855217] I(1,4,5)P3 transports from the ER lumen to the cytosol - Homo sapiens [Reaction:R-HSA-167686] Active PLCG1 hydrolyses PIP2 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-12-04
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9968059] Hill, David P, 2025-10-08 [InstanceEdit:9977084] Hill, David P, 2025-12-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1855190
summation	[Summation:2023896] Inositol 1,4,5-trisphosphate (I(1,4,5)P3) translocates from ...
updateTrackers	[UpdateTracker:9984670] Update Tracker - [Reaction:1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - v96:[removeCatalystActivity] [UpdateTracker:9964764] Update Tracker - [Reaction:1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - v94:[removeCatalystActivity] [UpdateTracker:9971899] Update Tracker - [Reaction:1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - v95:[addCatalystActivity, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9984670] Update Tracker - [Reaction:1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - v96:[removeCatalystActivity] [UpdateTracker:9964764] Update Tracker - [Reaction:1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - v94:[removeCatalystActivity] [UpdateTracker:9971899] Update Tracker - [Reaction:1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - v95:[addCatalystActivity, modifyText]
(hasEvent)	[Pathway:R-HSA-1855196] IP3 and IP4 transport between cytosol and nucleus
(precedingEvent)	[Reaction:R-HSA-1855233] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus

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