Reactome | I(1,4,5)P3 transports from the ER lumen to the cytosol

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I(1,4,5)P3 transports from the ER lumen to the cytosol Show undefined attributes

authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:9954154] myo-inositol transmembrane transporter activity of unknown PI transporter [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:70101] cytosol
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
dbId	1855217
displayName	I(1,4,5)P3 transports from the ER lumen to the cytosol
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf	[Pathway:R-HSA-1855215] IPs transport between ER lumen and cytosol - Homo sapiens
followingEvent	[Reaction:R-HSA-1855174] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol - Homo sapiens [Reaction:R-HSA-1855222] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane - Homo sapiens [Reaction:R-HSA-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Homo sapiens [Reaction:R-HSA-1855153] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol - Homo sapiens [Reaction:R-HSA-169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel - Homo sapiens
input	[SimpleEntity:R-ALL-2024016] I(1,4,5)P3 [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1889863] The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification [LiteratureReference:1889793] Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19
maxDepth	1
modified	[InstanceEdit:9956891] D'Eustachio, Peter, 2025-06-16
name	I(1,4,5)P3 transports from the ER lumen to the cytosol
output	[SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
precedingEvent	[Reaction:R-HSA-1855200] I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06 [InstanceEdit:9956890] Hill, David P, 2025-06-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1855217
summation	[Summation:2024017] Inositol 1,4,5-trisphosphate (I(1,4,5)P3) translocates from ...
updateTrackers	[UpdateTracker:9964605] Update Tracker - [Reaction:1855217] I(1,4,5)P3 transports from the ER lumen to the cytosol - v94:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9964605] Update Tracker - [Reaction:1855217] I(1,4,5)P3 transports from the ER lumen to the cytosol - v94:[removeCatalystActivity]
(precedingEvent)	[Reaction:R-HSA-1855174] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol [Reaction:R-HSA-1855222] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane [Reaction:R-HSA-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus [Reaction:R-HSA-169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel [Reaction:R-HSA-1855153] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
(hasEvent)	[Pathway:R-HSA-1855215] IPs transport between ER lumen and cytosol