Reactome | I(1,4,5)P3 transports from the cytosol to the nucleus

Schema > Reaction > Entries

I(1,4,5)P3 transports from the cytosol to the nucleus Show undefined attributes

catalystActivity	[CatalystActivity:10597876] narrow pore channel activity of Nuclear Pore Complex (NPC) [nuclear envelope]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10597968
displayName	I(1,4,5)P3 transports from the cytosol to the nucleus
eventOf	[Pathway:R-DRE-1855196] IP3 and IP4 transport between cytosol and nucleus - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-1855233] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus - Danio rerio
goBiologicalProcess	[GO_BiologicalProcess:160267] import into nucleus
inferredFrom	[Reaction:R-HSA-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus - Homo sapiens
input	[SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	I(1,4,5)P3 transports from the cytosol to the nucleus
output	[SimpleEntity:R-ALL-2023907] I(1,4,5)P3 [nucleoplasm]
precedingEvent	[Reaction:R-DRE-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Danio rerio [Reaction:R-DRE-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Danio rerio [Reaction:R-DRE-1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane - Danio rerio [Reaction:R-DRE-1855205] I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-1855190
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1855196] IP3 and IP4 transport between cytosol and nucleus
(precedingEvent)	[Reaction:R-DRE-1855233] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus
(inferredTo)	[Reaction:R-HSA-1855190] I(1,4,5)P3 transports from the cytosol to the nucleus