Reactome | 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol

5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol

Stable Identifier

R-HSA-1855182

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol

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Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1/2 (PPIP5K1) and 2 (PPIP5K2) phosphorylate inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5) to inositol 1,5-bisdiphospho-2,3,4,6-tetrakisphosphate (1,5-(PP)2-IP4) (Fridy et al. 2007, Mulugu et al. 2007, Choi et al. 2007, Lin et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
18981179	Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases Lin, H, Fridy, PC, Ribeiro, AA, Choi, JH, Barma, DK, Vogel, G, Falck, JR, Shears, SB, York, JD, Mayr, GW	J Biol Chem	2009
17702752	Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress Choi, JH, Williams, J, Cho, J, Falck, JR, Shears, SB	J Biol Chem	2007
17690096	Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases Fridy, PC, Otto, JC, Dollins, DE, York, JD	J Biol Chem	2007
17412958	A conserved family of enzymes that phosphorylate inositol hexakisphosphate Mulugu, S, Bai, W, Fridy, PC, Bastidas, RJ, Otto, JC, Dollins, DE, Haystead, TA, Ribeiro, AA, York, JD	Science	2007