Phosphorylation of STAT5 by cytosolic FGFR1 fusions

Stable Identifier
R-HSA-1839112
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activation of a subset of FGFR1-fusions (ZMYM2, BCR, FGFR1OP2 and CUX) has been shown to result in downstream phosphorylation of STAT5 proteins at Y694. This phosphorylation is dependent on the FGFR1 fusion, as the STAT5 phosphorylation is abrogated in the presence of an FGFR1-kinase dead fusion (Heath and Cross, 2004; Smedley, 1999; Chase, 2007; Wasage, 2011).

Literature References
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of cytosolic p-FGFR1 fusion mutant dimers [cytosol]

Functional status

Gain of function of cytosolic p-FGFR1 fusion mutant dimers [cytosol]

Disease Entity
Status
Disease
Name Identifier Synonyms
precursor lymphoblastic lymphoma/leukemia DOID:5600
subacute leukemia DOID:3264
myelodysplastic myeloproliferative cancer DOID:4972 Myeloproliferative/Myelodysplastic syndromes, unclassifiable myelodysplastic myeloproliferative disease, Unclassifiable Myeloproliferative/Myelodysplastic syndrome, Myelodysplastic/myeloproliferative disease (morphologic abnormality)
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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