By analogy with the wild-type pathway, PLC-gamma is presumed to be phosphorylated by activated FGFR mutants, resulting in PLC-gamma activation, stimulation of phosphatidyl inositol hydrolysis and generation of two second messengers, diacylglycerol and inositol (1,4,5) P3.
Ji, Q, Carpenter, G
protein tyrosine kinase activity of Activated FGFR1 mutants and fusions:PLCG1 [cytosol]
Gain of function of Activated FGFR1 mutants and fusions:PLCG1 [cytosol]
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