Activated FGFR1 mutants and fusions phosphorylate PLCG1

Stable Identifier
R-HSA-1839098
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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By analogy with the wild-type pathway, PLC-gamma is presumed to be phosphorylated by activated FGFR mutants, resulting in PLC-gamma activation, stimulation of phosphatidyl inositol hydrolysis and generation of two second messengers, diacylglycerol and inositol (1,4,5) P3.
Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Ji, Q, Carpenter, G

Exp Cell Res 1999
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of Activated FGFR1 mutants and fusions:PLCG1 [cytosol]

Normal reaction
Functional status

Gain of function of Activated FGFR1 mutants and fusions:PLCG1 [cytosol]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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