Reactome | p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-1839043] pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] - Homo sapiens [Complex:R-HSA-1839043] pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] - Homo sapiens
created	[InstanceEdit:1839040] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020829] Mondo:0006311
dbId	1839041
disease	[Disease:1247687] chronic myeloid leukemia [Disease:1614677] myelodysplastic myeloproliferative cancer [Disease:2317476] acute lymphocytic leukemia
displayName	p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
endCoordinate	584
hasModifiedResidue	[FragmentInsertionModification:1604522] Insertion of residues 429 to 822 at 585 from UniProt:P11362 FGFR1 [ModifiedResidue:1838976] O4'-phospho-L-tyrosine at 766 [ModifiedResidue:1839010] O4'-phospho-L-tyrosine at 177 [ModifiedResidue:1838977] O4'-phospho-L-tyrosine at unknown position
inDisease	true
literatureReference	[LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins
maxDepth	1
modified	[InstanceEdit:9832769] Orlic-Milacic, Marija, 2023-04-07
name	p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion p-Y177-BCR-p-FGFR1 fusion t(8:22) BCR-p-FGFR1 fusion
referenceEntity	[ReferenceGeneProduct:uniprot:P11274] UniProt:P11274 BCR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1839041
startCoordinate	1
updateTrackers	[UpdateTracker:9873624] Update Tracker - [EntityWithAccessionedSequence:1839041] p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] - v43:[modifyName] [UpdateTracker:9905524] Update Tracker - [EntityWithAccessionedSequence:1839041] p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] - v85:[add_removeDisease, modifyName] [UpdateTracker:9902922] Update Tracker - [EntityWithAccessionedSequence:1839041] p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] - v79:[modifyName] [UpdateTracker:9891199] Update Tracker - [EntityWithAccessionedSequence:1839041] p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] - v52:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9873624] Update Tracker - [EntityWithAccessionedSequence:1839041] p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] - v43:[modifyName] [UpdateTracker:9905524] Update Tracker - [EntityWithAccessionedSequence:1839041] p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] - v85:[add_removeDisease, modifyName] [UpdateTracker:9902922] Update Tracker - [EntityWithAccessionedSequence:1839041] p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] - v79:[modifyName] [UpdateTracker:9891199] Update Tracker - [EntityWithAccessionedSequence:1839041] p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] - v52:[modifyName]
(activeUnit)	[CatalystActivity:1839105] protein tyrosine kinase activity of pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol]
(hasComponent)	[Complex:R-HSA-1839043] pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol]