Localization of CBL:GRB2 to the membrane

Stable Identifier
R-HSA-183067
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
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Localization of CBL:GRB2 to the membrane
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Upon EGF stimulation and consequent EGFR phosphorylation, GRB2 binds phosphorylated tyrosines
Literature References
PubMed ID Title Journal Year
11823423 A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

Elson, A, Waterman, H, Katz, M, Yarden, Y, Rubin, C, Lavi, S, Shtiegman, K, Jovin, T

EMBO J 2002
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Orthologous Events
Localization of CBL:GRB2 to the membrane (Bos taurus)
Localization of CBL:GRB2 to the membrane (Caenorhabditis elegans)
Localization of CBL:GRB2 to the membrane (Canis familiaris)
Localization of CBL:GRB2 to the membrane (Danio rerio)
Localization of CBL:GRB2 to the membrane (Drosophila melanogaster)
Localization of CBL:GRB2 to the membrane (Gallus gallus)
Localization of CBL:GRB2 to the membrane (Mus musculus)
Localization of CBL:GRB2 to the membrane (Rattus norvegicus)
Localization of CBL:GRB2 to the membrane (Sus scrofa)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)
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