Localization of CBL:GRB2 to the membrane

Stable Identifier
R-HSA-183067
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
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Localization of CBL:GRB2 to the membrane
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Upon EGF stimulation and consequent EGFR phosphorylation, GRB2 binds phosphorylated tyrosines

Literature References
PubMed ID Title Journal Year
11823423 A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

Waterman, H, Katz, M, Rubin, C, Shtiegman, K, Lavi, S, Elson, A, Jovin, T, Yarden, Y

EMBO J 2002
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Localization of CBL:GRB2 to the membrane (Bos taurus)
Localization of CBL:GRB2 to the membrane (Caenorhabditis elegans)
Localization of CBL:GRB2 to the membrane (Canis familiaris)
Localization of CBL:GRB2 to the membrane (Danio rerio)
Localization of CBL:GRB2 to the membrane (Drosophila melanogaster)
Localization of CBL:GRB2 to the membrane (Mus musculus)
Localization of CBL:GRB2 to the membrane (Rattus norvegicus)
Localization of CBL:GRB2 to the membrane (Sus scrofa)
Localization of CBL:GRB2 to the membrane (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)