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Schema
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Reaction
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Entries
Association of INK4 family proteins with CDK4/6
Show undefined attributes
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authored
[InstanceEdit:182593] Matthews, L, 2006-07-10 19:18:57
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:182593] Matthews, L, 2006-07-10 19:18:57
dbId
182594
diseaseReaction
[FailedReaction:R-HSA-9630795] p16INK4A mutants do not bind CDK4,CDK6 - Homo sapiens
[FailedReaction:R-HSA-9630792] p16INK4A mutants do not bind CDK4 - Homo sapiens
displayName
Association of INK4 family proteins with CDK4/6
edited
[InstanceEdit:167002] Matthews, L, 2005-10-07 06:13:50
[InstanceEdit:8941988] Orlic-Milacic, Marija, 2016-10-07
eventOf
[Pathway:R-HSA-69231] Cyclin D associated events in G1 - Homo sapiens
[Pathway:R-HSA-2559585] Oncogene Induced Senescence - Homo sapiens
[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP) - Homo sapiens
[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:1043034] negative regulation of G1/S transition of mitotic cell cycle
input
[DefinedSet:R-HSA-69209] CDK4,CDK6 [cytosol]
[DefinedSet:R-HSA-182588] INK4 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:182601] A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
[LiteratureReference:182566] p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
[LiteratureReference:182595] Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
[LiteratureReference:182600] Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4
[LiteratureReference:8941982] Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
Association of INK4 family proteins with CDK4/6
orthologousEvent
[Reaction:R-GGA-182594] Association of INK4 family proteins with CDK4/6 - Gallus gallus
[Reaction:R-XTR-182594] Association of INK4 family proteins with CDK4/6 - Xenopus tropicalis
[Reaction:R-DRE-182594] Association of INK4 family proteins with CDK4/6 - Danio rerio
[Reaction:R-SSC-182594] Association of INK4 family proteins with CDK4/6 - Sus scrofa
[Reaction:R-BTA-182594] Association of INK4 family proteins with CDK4/6 - Bos taurus
[Reaction:R-CFA-182594] Association of INK4 family proteins with CDK4/6 - Canis familiaris
[Reaction:R-RNO-182594] Association of INK4 family proteins with CDK4/6 - Rattus norvegicus
[Reaction:R-MMU-182594] Association of INK4 family proteins with CDK4/6 - Mus musculus
output
[Complex:R-HSA-182579] CDK4,CDK6:INK4 [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-3209114] Translation of p16INK4A mRNA is inhibited by miR-24 - Homo sapiens
[BlackBoxEvent:R-HSA-3857348] Activated CEBPB stimulates transcription of CDKN2B - Homo sapiens
[BlackBoxEvent:R-HSA-2187303] SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B - Homo sapiens
releaseDate
2006-08-02
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
[InstanceEdit:8949903] Roger, Pierre P, 2016-11-04
[InstanceEdit:9645278] Bennett, Dorothy C, 2019-04-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-182594
summation
[Summation:182625] Prior to mitogen activation, the inhibitory proteins of the ...
updateTrackers
[UpdateTracker:9777817] Update Tracker - [Reaction:182594] Association of INK4 family proteins with CDK4/6 - v69:[modifyText]
[UpdateTracker:9787429] Update Tracker - [Reaction:182594] Association of INK4 family proteins with CDK4/6 - v45:[modifyText]
[UpdateTracker:9782433] Update Tracker - [Reaction:182594] Association of INK4 family proteins with CDK4/6 - v59:[addLiteratureReference, modifyText]
[UpdateTracker:9781607] Update Tracker - [Reaction:182594] Association of INK4 family proteins with CDK4/6 - v60:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9777817] Update Tracker - [Reaction:182594] Association of INK4 family proteins with CDK4/6 - v69:[modifyText]
[UpdateTracker:9787429] Update Tracker - [Reaction:182594] Association of INK4 family proteins with CDK4/6 - v45:[modifyText]
[UpdateTracker:9782433] Update Tracker - [Reaction:182594] Association of INK4 family proteins with CDK4/6 - v59:[addLiteratureReference, modifyText]
[UpdateTracker:9781607] Update Tracker - [Reaction:182594] Association of INK4 family proteins with CDK4/6 - v60:[modifyText]
(normalReaction)
[FailedReaction:R-HSA-9630795] p16INK4A mutants do not bind CDK4,CDK6
[FailedReaction:R-HSA-9630792] p16INK4A mutants do not bind CDK4
(hasEvent)
[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
[Pathway:R-HSA-2559585] Oncogene Induced Senescence
[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP)
[Pathway:R-HSA-69231] Cyclin D associated events in G1
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