Association of INK4 family proteins with CDK4/6

Stable Identifier
Reaction [binding]
Homo sapiens
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Prior to mitogen activation, the inhibitory proteins of the INK4 family (p15, p16, p18, and p19) associate with the catalytic domains of free CDK4 and CDK6, preventing their association with D type cyclins (CCND1, CCND2 and CCND3), and thus their activation and their inhibitory phosphorylation of the RB family (Serrano et al. 1993, Hannon and Beach 1994, Guan et al. 1994, Guan et al. 1996, Parry et al. 1995). Inactivation and defects of RB1 strongly upregulate p16INK4A (Parry et al. 1995).
Literature References
PubMed ID Title Journal Year
8259215 A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

Hannon, GJ, Serrano, M, Beach, D

Nature 1993
8741839 Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4

Matera, AG, Xiong, Y, Guan, KL, Zariwala, M, Li, Y, O'Keefe, CL, Noh, S, Wu, X, Jenkins, CW

Mol Biol Cell 1996
7859739 Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product

Peters, G, Bates, S, Mann, DJ, Parry, D

EMBO J. 1995
8078588 p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

Hannon, GJ, Beach, D

Nature 1994
8001816 Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

Matera, AG, Xiong, Y, Guan, KL, Nichols, MA, Li, Y, O'Keefe, CL, Wu, X, Jenkins, CW

Genes Dev 1994
Event Information
Orthologous Events
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