Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex

Stable Identifier
R-HSA-182186
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
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The presence of Nef accelerates endocytosis and lysosomal degradation of the transmembrane glycoprotein CD8. Nef facilitates a cascade of protein interactions that ultimately result in the degradation of internalized CD8 protein. The final set of protein interactions that direct Nef to the beta-subunit of the COPI coatomers are at this time unclear.
A number of sites within Nef are proposed to be required for CD8 down-regulation, the myristoylation signal and N-terminal anchor regions, the C-terminal flexible loop, and amino acid positions 57 to 58. Consistent with all reported Nef functions, the myristoylation signal was found to be essential for CD8 down-modulation. The flexible loop contains a dileucine-based internalization motif, which is flanked by acidic clusters and is involved in enhanced internalization of the Nef-CD4 complex.

Literature References
PubMed ID Title Journal Year
16103193 Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta

Stove, V, Van de Walle, I, Naessens, E, Coene, E, Stove, C, Plum, J, Verhasselt, B

J Virol 2005
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created
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