Reactome | botC LC cleaves target cell STX1

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botC LC cleaves target cell STX1 Show undefined attributes

authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
catalystActivity	[CatalystActivity:168781] metalloendopeptidase activity of botC LC:Zn2+ [cytosol]
catalystActivityReference	[CatalystActivityReference:9643247] metalloendopeptidase activity of BoNT/C LC:Zn2+ [cytosol] Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:181561] Gopinathrao, G, 2006-06-14 16:40:11
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	181567
deleted	[Deleted:5251013] Deletion of instance: 168782 [Deleted:5251002] Deletion of instance: 181546
disease	[Disease:3632909] botulism
displayName	botC LC cleaves target cell STX1
edited	[InstanceEdit:181692] Gopinathrao, G, 2006-06-15 22:12:29
eventOf	[Pathway:R-HSA-5250971] Toxicity of botulinum toxin type C (botC) - Homo sapiens
input	[DefinedSet:R-HSA-5250514] STX1 [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5246522] Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin [LiteratureReference:181711] Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release [LiteratureReference:5263580] Membrane fusion machinery: insights from synaptic proteins [LiteratureReference:379281] The synaptic vesicle cycle
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	botC LC cleaves target cell STX1
output	[DefinedSet:R-HSA-5250515] STX1(1-?) [cytosol] [DefinedSet:R-HSA-5250513] STX1(?-288) [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-5246514] botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol - Homo sapiens
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-181567
summation	[Summation:181687] Botulinum toxin type C light chain (botC LC), in the cytosol...
updateTrackers	[UpdateTracker:9776522] Update Tracker - [Reaction:181567] botC LC cleaves target cell STX1 - v75:[modifyText] [UpdateTracker:9786729] Update Tracker - [Reaction:181567] botC LC cleaves target cell STX1 - v48:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9786326] Update Tracker - [Reaction:181567] botC LC cleaves target cell STX1 - v50:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776522] Update Tracker - [Reaction:181567] botC LC cleaves target cell STX1 - v75:[modifyText] [UpdateTracker:9786729] Update Tracker - [Reaction:181567] botC LC cleaves target cell STX1 - v48:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9786326] Update Tracker - [Reaction:181567] botC LC cleaves target cell STX1 - v50:[modifyText]
(replacementInstances)	[Deleted:5251013] Deletion of instance: 168782 [Deleted:5251002] Deletion of instance: 181546
(hasEvent)	[Pathway:R-HSA-5250971] Toxicity of botulinum toxin type C (botC)

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