Botulinum toxin type C light chain (botC LC), in the cytosol...

created [InstanceEdit:181679] Gopinathrao, G, 2006-06-15 22:12:23
dbId 181687
displayName Botulinum toxin type C light chain (botC LC), in the cytosol...
modified [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08
schemaClass Summation
text Botulinum toxin type C light chain (botC LC), in the cytosol of a target cell, catalyzes the removal of an aminoterminal peptide from syntaxin 1 (STX1). botC LC is a zinc metalloprotease (Blasi et al. 1993; Foran et al. 1994). STX1 is associated with the cytosolic face of the target cell plasma membrane where it forms part of a complex required for synaptic vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release (Sudhof et al, 1993; Sudhof 2004).
Cite Us!