Botulinum toxin type C light chain (botC LC), in the cytosol of a target cell, catalyzes the removal of an aminoterminal peptide from syntaxin 1 (STX1). botC LC is a zinc metalloprotease (Blasi et al. 1993; Foran et al. 1994). STX1 is associated with the cytosolic face of the target cell plasma membrane where it forms part of a complex required for synaptic vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release (Sudhof et al, 1993; Sudhof 2004).
Shone, CC, Lawrence, GW, Foster, KA, Foran, P, Dolly, JO
Südhof, TC, Niemann, H, Jahn, R, De Camilli, P
Chapman, ER, Yamasaki, S, Niemann, H, Binz, T, Jahn, R, Blasi, J
Südhof, TC
metalloendopeptidase activity of botC LC:Zn2+ [cytosol]
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