botC LC cleaves target cell STX1

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Clostridium botulinum
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Botulinum toxin type C light chain (botC LC), in the cytosol of a target cell, catalyzes the removal of an aminoterminal peptide from syntaxin 1 (STX1). botC LC is a zinc metalloprotease (Blasi et al. 1993; Foran et al. 1994). STX1 is associated with the cytosolic face of the target cell plasma membrane where it forms part of a complex required for synaptic vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release (Sudhof et al, 1993; Sudhof 2004).

Literature References
PubMed ID Title Journal Year
8611567 Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release

Shone, CC, Lawrence, GW, Foster, KA, Foran, P, Dolly, JO

Biochemistry 1996
8402889 Membrane fusion machinery: insights from synaptic proteins

Südhof, TC, Niemann, H, Jahn, R, De Camilli, P

Cell 1993
7901002 Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin

Chapman, ER, Yamasaki, S, Niemann, H, Binz, T, Jahn, R, Blasi, J

EMBO J. 1993
15217342 The synaptic vesicle cycle

Südhof, TC

Annu Rev Neurosci 2004
Catalyst Activity

metalloendopeptidase activity of botC LC:Zn2+ [cytosol]

Name Identifier Synonyms
botulism DOID:11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
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