Reactome | Vpu:CD4 associates with beta-TrCP

Schema > Reaction > Entries

Vpu:CD4 associates with beta-TrCP Show undefined attributes

authored	[InstanceEdit:180608] Matthews, L, 2006-05-15 07:16:46
category	binding
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:180586] Matthews, L, 2006-05-23 13:59:44
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	180591
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Vpu:CD4 associates with beta-TrCP
edited	[InstanceEdit:180608] Matthews, L, 2006-05-15 07:16:46
eventOf	[Pathway:R-HSA-180534] Vpu mediated degradation of CD4 - Homo sapiens
followingEvent	[Reaction:R-HSA-180599] The Vpu:CD4:beta-TrCP complex recruits SKP1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-174237] BTRC [cytosol] [Complex:R-HSA-180601] CD4:Vpu complex [endoplasmic reticulum membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:180533] A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Vpu:CD4 associates with beta-TrCP
output	[Complex:R-HSA-180532] CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-180606] Association of Vpu with CD4 - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188242] Benarous, R, 2006-09-21 14:25:23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-180591
summation	[Summation:188235] Vpu links beta-TrCP to CD4 at the ER membrane through intera...

Referrals

(hasEvent)	[Pathway:R-HSA-180534] Vpu mediated degradation of CD4
(precedingEvent)	[Reaction:R-HSA-180599] The Vpu:CD4:beta-TrCP complex recruits SKP1

Cite Us!