Reactome | Vpu mediated degradation of CD4

Schema > Pathway > Entries

Vpu mediated degradation of CD4 Show undefined attributes

authored	[InstanceEdit:180608] Matthews, L, 2006-05-15 07:16:46
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:180586] Matthews, L, 2006-05-23 13:59:44
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	180534
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Vpu mediated degradation of CD4
edited	[InstanceEdit:180608] Matthews, L, 2006-05-15 07:16:46
eventOf	[Pathway:R-HSA-162909] Host Interactions of HIV factors - Homo sapiens
figure	[Figure:188239] /figures/Vpu.jpg
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-180606] Association of Vpu with CD4 - Homo sapiens [Reaction:R-HSA-180591] Vpu:CD4 associates with beta-TrCP - Homo sapiens [Reaction:R-HSA-180599] The Vpu:CD4:beta-TrCP complex recruits SKP1 - Homo sapiens [Reaction:R-HSA-180597] Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex - Homo sapiens [BlackBoxEvent:R-HSA-180573] Degradation of ubiquitinated CD4 - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:180703] Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions [LiteratureReference:187055] Recent advances in the understanding of HIV-1 Vpu accessory protein functions
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Vpu mediated degradation of CD4
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188242] Benarous, R, 2006-09-21 14:25:23
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-180534
summation	[Summation:180947] The HIV-1 Vpu protein promotes the degradation of the CD4 re...
updateTrackers	[UpdateTracker:9789853] Update Tracker - [Pathway:180534] Vpu mediated degradation of CD4 - v37:[modifyText, updateContainedRLE] [UpdateTracker:9789018] Update Tracker - [Pathway:180534] Vpu mediated degradation of CD4 - v39:[modifyText] [UpdateTracker:9782375] Update Tracker - [Pathway:180534] Vpu mediated degradation of CD4 - v59:[updateContainedRLE] [UpdateTracker:9787714] Update Tracker - [Pathway:180534] Vpu mediated degradation of CD4 - v44:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9789853] Update Tracker - [Pathway:180534] Vpu mediated degradation of CD4 - v37:[modifyText, updateContainedRLE]
[UpdateTracker:9789018] Update Tracker - [Pathway:180534] Vpu mediated degradation of CD4 - v39:[modifyText]
[UpdateTracker:9782375] Update Tracker - [Pathway:180534] Vpu mediated degradation of CD4 - v59:[updateContainedRLE]
[UpdateTracker:9787714] Update Tracker - [Pathway:180534] Vpu mediated degradation of CD4 - v44:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-162909] Host Interactions of HIV factors