Vpu:CD4 associates with beta-TrCP

Stable Identifier
R-HSA-180591
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
General
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Vpu links beta-TrCP to CD4 at the ER membrane through interactions with beta-TrCP and the cytoplasmic tail of CD4.

Literature References
PubMed ID Title Journal Year
9660940 A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

Margottin, F, Bour, SP, Durand, H, Selig, L, Benichou, S, Richard, V, Thomas, D, Strebel, K, Benarous, R

Mol Cell 1998
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created