Reactome | Degradation of ubiquitinated CD4

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Degradation of ubiquitinated CD4 Show undefined attributes

authored	[InstanceEdit:180608] Matthews, L, 2006-05-15 07:16:46
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:180586] Matthews, L, 2006-05-23 13:59:44
dbId	180573
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Degradation of ubiquitinated CD4
edited	[InstanceEdit:180608] Matthews, L, 2006-05-15 07:16:46
eventOf	[Pathway:R-HSA-180534] Vpu mediated degradation of CD4 - Homo sapiens
input	[Complex:R-HSA-180530] multiubiquitinated CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:180533] A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Degradation of ubiquitinated CD4
output	3 × [DefinedSet:R-HSA-113595] Ub [cytosol] [Complex:R-HSA-180567] Vpu:beta-TrCP1:Skp1 complex [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-180597] Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188242] Benarous, R, 2006-09-21 14:25:23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-180573
summation	[Summation:188232] Ubiquitinated CD4 is then subject to proteasome-mediated deg...

Referrals

(hasEvent)

[Pathway:R-HSA-180534] Vpu mediated degradation of CD4

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