Degradation of ubiquitinated CD4

Stable Identifier
R-HSA-180573
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
ReviewStatus
5/5
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Degradation of ubiquitinated CD4
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Ubiquitinated CD4 is then subject to proteasome-mediated degradation.
Literature References
PubMed ID Title Journal Year
9660940 A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

Margottin, F, Bour, SP, Durand, H, Selig, L, Benichou, S, Richard, V, Thomas, D, Strebel, K, Benarous, R

Mol Cell 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Cross References
Mondo
Authored
Matthews, L  (2006-05-15)
Reviewed
Benarous, R  (2006-09-21)
Created
Matthews, L  (2006-05-23)
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