Degradation of ubiquitinated CD4

Stable Identifier
R-HSA-180573
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Ubiquitinated CD4 is then subject to proteasome-mediated degradation.

Literature References
PubMed ID Title Journal Year
9660940 A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

Margottin, F, Bour, SP, Durand, H, Selig, L, Benichou, S, Richard, V, Thomas, D, Strebel, K, Benarous, R

Mol Cell 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created