Activation of SHP2 through the binding to phospho-Gab1

Stable Identifier
R-HSA-177944
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of SHP2 through the binding to phospho-Gab1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The SH2 domains repress phosphatase activity of SHP2. Binding of these domains to phosphotyrosine-containing proteins relieves this autoinhibition, possibly by inducing a conformational change in the enzyme.

Literature References
Participants
Input
Output
Participates
as an event of
Orthologous Events
Activation of SHP2 through the binding to phospho-Gab1 (Bos taurus)
Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)
Activation of SHP2 through the binding to phospho-Gab1 (Gallus gallus)
Activation of SHP2 through the binding to phospho-Gab1 (Mus musculus)
Activation of SHP2 through the binding to phospho-Gab1 (Rattus norvegicus)
Activation of SHP2 through the binding to phospho-Gab1 (Sus scrofa)
Activation of SHP2 through the binding to phospho-Gab1 (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)
Cite Us!