Activation of SHP2 through the binding to phospho-Gab1

Stable Identifier
R-HSA-177944
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The SH2 domains repress phosphatase activity of SHP2. Binding of these domains to phosphotyrosine-containing proteins relieves this autoinhibition, possibly by inducing a conformational change in the enzyme.

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Orthologous Events
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