viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane]

Stable Identifier
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
20047764 Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

Sasai, M, Tatematsu, M, Oshiumi, H, Funami, K, Matsumoto, M, Hatakeyama, S, Seya, T

Mol Immunol 2010
16115877 Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

Cusson-Hermance, N, Khurana, S, Lee, TH, Fitzgerald, KA, Kelliher, MA

J Biol Chem 2005
14982987 Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta

Jiang, Z, Mak, TW, Sen, G, Li, X

Proc. Natl. Acad. Sci. U.S.A. 2004
16306937 Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

Häcker, H, Redecke, V, Blagoev, B, Kratchmarova, I, Hsu, LC, Wang, GG, Kamps, MP, Raz, E, Wagner, H, Häcker, G, Mann, M, Karin, M

Nature 2006
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