Reactome | viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane]

Stable Identifier

R-HSA-177689

Type

Complex

Species

Homo sapiens

Related Species

Influenza A virus, Rotavirus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1

Compartment

endosome membrane

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
16115877	Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation Fitzgerald, KA, Cusson-Hermance, N, Khurana, S, Kelliher, MA, Lee, TH	J Biol Chem	2005
12609980	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR Jiang, Z, Nie, H, Li, X, Williams, BR, Zamanian-Daryoush, M, Silva, AM	J Biol Chem	2003

Participants

components

Participates

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