Reactome | RFC binding displaces Pol Alpha on the C-strand of the telomere

Schema > Reaction > Entries

RFC binding displaces Pol Alpha on the C-strand of the telomere Show undefined attributes

authored	[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
category	dissociation
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174443] Gillespie, ME, 2006-02-17 20:47:42
dbId	174452
displayName	RFC binding displaces Pol Alpha on the C-strand of the telomere
edited	[InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
eventOf	[Pathway:R-HSA-174411] Polymerase switching on the C-strand of the telomere - Homo sapiens
followingEvent	[Reaction:R-HSA-174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
input	[CandidateSet:R-HSA-9668941] RFC,(CFT18-RFC) [nucleoplasm] [Complex:R-HSA-174433] RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9668872] Replication factor C recognizes 5'-phosphate ends of telomeres [LiteratureReference:9668873] Characterization of telomere-binding activity of replication factor C large subunit p140
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	RFC binding displaces Pol Alpha on the C-strand of the telomere
negativePrecedingEvent	[NegativePrecedingEvent:9766493] Futile Cycle: RFC dissociates after sliding clamp formation on the C-strand of the telomere
orthologousEvent	[Reaction:R-GGA-174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - Gallus gallus [Reaction:R-SSC-174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - Sus scrofa [Reaction:R-BTA-174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - Bos taurus [Reaction:R-CFA-174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - Canis familiaris [Reaction:R-RNO-174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - Rattus norvegicus [Reaction:R-MMU-174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - Mus musculus
output	[Complex:R-HSA-9668830] CST complex [nucleoplasm] [Complex:R-HSA-68507] DNA polymerase alpha:primase [nucleoplasm] [Complex:R-HSA-174454] RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm]
precedingEvent	[Reaction:R-HSA-174427] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere - Homo sapiens [Reaction:R-HSA-9668902] Formation of the CTF18-RFC(7s) complex - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38 [InstanceEdit:9672970] Gillespie, Marc E, 2020-01-03 [InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
revised	[InstanceEdit:9671059] Orlic-Milacic, Marija, 2019-12-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174452
summation	[Summation:69054] Once the RNA-DNA primer is synthesized, replication factor C...
updateTrackers	[UpdateTracker:9777039] Update Tracker - [Reaction:174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - v73:[addOutput, modifyText] [UpdateTracker:9777406] Update Tracker - [Reaction:174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - v72:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777039] Update Tracker - [Reaction:174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - v73:[addOutput, modifyText] [UpdateTracker:9777406] Update Tracker - [Reaction:174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - v72:[addLiteratureReference, add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-174411] Polymerase switching on the C-strand of the telomere
(precedingEvent)	[Reaction:R-HSA-174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere [NegativePrecedingEvent:9766487] Futile Cycle: RFC binding displaces Pol Alpha on the C-strand of the telomere [NegativePrecedingEvent:9766489] Futile Cycle: RFC binding displaces Pol Alpha on the C-strand of the telomere

Cite Us!