Reactome | GSS:Mg2+ dimer synthesizes GSH

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GSS:Mg2+ dimer synthesizes GSH Show undefined attributes

catalystActivity	[CatalystActivity:10743673] glutathione synthase activity of GSS:Mg2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10743675
displayName	GSS:Mg2+ dimer synthesizes GSH
eventOf	[Pathway:R-GGA-174403] Glutathione synthesis and recycling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-176059] GST trimers transfer GS from GSH to luminal substrates - Gallus gallus [Reaction:R-GGA-176054] GST dimers conjugate GSH with cytosolic substrates - Gallus gallus [Reaction:R-GGA-6785928] CHAC1,2 cleaves GSH to OPRO and CysGly - Gallus gallus [Reaction:R-GGA-9753280] GSTs transfer GSH to NAPQI to form APAP-SG - Gallus gallus
inferredFrom	[Reaction:R-HSA-174394] GSS:Mg2+ dimer synthesizes GSH - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-174393] gGluCys [cytosol] [SimpleEntity:R-ALL-29424] Gly [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GSS:Mg2+ dimer synthesizes GSH gamma-glutamylcysteine combines with glycine to form glutathione
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-GGA-174367] GCL ligates L-Glu to L-Cys - Gallus gallus [Reaction:R-GGA-1247910] CNDP2:2Mn2+ dimer hydrolyses CysGly - Gallus gallus
regulatedBy	[NegativeRegulation:R-HSA-1260991] Negative regulation by 'GSH [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-174394
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-GGA-9753280] GSTs transfer GSH to NAPQI to form APAP-SG [Reaction:R-GGA-176059] GST trimers transfer GS from GSH to luminal substrates [Reaction:R-GGA-176054] GST dimers conjugate GSH with cytosolic substrates [Reaction:R-GGA-6785928] CHAC1,2 cleaves GSH to OPRO and CysGly
(hasEvent)	[Pathway:R-GGA-174403] Glutathione synthesis and recycling
(inferredTo)	[Reaction:R-HSA-174394] GSS:Mg2+ dimer synthesizes GSH