Reactome | Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex

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Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex Show undefined attributes

authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
catalystActivity	[CatalystActivity:9764125] ubiquitin-protein transferase activity of Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
dbId	174227
displayName	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
edited	[InstanceEdit:174183] Matthews, L, 2006-01-30 00:00:00
eventOf	[Pathway:R-HSA-174048] APC/C:Cdc20 mediated degradation of Cyclin B - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-174157] Degradation of multiubiquitinated Cyclin B - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:7441] ubiquitin-dependent protein catabolic process
input	[Complex:R-HSA-174095] Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] 4 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:174075] Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
negativePrecedingEvent	[NegativePrecedingEvent:9764077] Futile Cycle: Degradation multiubiquitinated Cyclin A [NegativePrecedingEvent:9764095] Futile Cycle: Degradation of multiubiquitinated Nek2A [NegativePrecedingEvent:9764103] Futile Cycle: Degradation of multiubiquitinated cell cycle proteins [NegativePrecedingEvent:9764117] Futile Cycle: SCF-mediated degradation of Emi1 [NegativePrecedingEvent:9764131] Futile Cycle: Degradation of multiubiquitinated Cyclin B [NegativePrecedingEvent:9764134] Futile Cycle: Degradation of multiubiquitinated Securin
orthologousEvent	[Reaction:R-DDI-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Dictyostelium discoideum [Reaction:R-DME-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Drosophila melanogaster [Reaction:R-GGA-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Gallus gallus [Reaction:R-XTR-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Xenopus tropicalis [Reaction:R-DRE-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Danio rerio [Reaction:R-SSC-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Sus scrofa [Reaction:R-BTA-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Bos taurus [Reaction:R-CFA-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Canis familiaris [Reaction:R-RNO-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-MMU-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Mus musculus
output	[Complex:R-HSA-174131] multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol]
precedingEvent	[Reaction:R-HSA-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - Homo sapiens
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174227
summation	[Summation:179283] At the beginning of this reaction, 1 molecule of 'Cdc20:phos...
updateTrackers	[UpdateTracker:9775010] Update Tracker - [Reaction:174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - v80:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9775010] Update Tracker - [Reaction:174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - v80:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-174048] APC/C:Cdc20 mediated degradation of Cyclin B
(precedingEvent)	[BlackBoxEvent:R-HSA-174157] Degradation of multiubiquitinated Cyclin B

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