Reactome | Association of Cyclin B:Cdc2 with Cdc20:APC/C complex

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Association of Cyclin B:Cdc2 with Cdc20:APC/C complex Show undefined attributes

authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
dbId	174120
displayName	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex
edited	[InstanceEdit:174183] Matthews, L, 2006-01-30 00:00:00
eventOf	[Pathway:R-HSA-174048] APC/C:Cdc20 mediated degradation of Cyclin B - Homo sapiens
followingEvent	[Reaction:R-HSA-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Homo sapiens
input	[Complex:R-HSA-157456] CCNB1:p-T161-CDK1 [cytosol] [Complex:R-HSA-174081] CDC20:p-APC/C [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:174075] Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex
negativePrecedingEvent	[NegativePrecedingEvent:9764143] Futile Cycle: Degradation of multiubiquitinated Cyclin B [NegativePrecedingEvent:9764138] Futile Cycle: Degradation of multiubiquitinated Securin
orthologousEvent	[Reaction:R-DME-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - Drosophila melanogaster [Reaction:R-XTR-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - Xenopus tropicalis [Reaction:R-DRE-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - Danio rerio [Reaction:R-SSC-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - Sus scrofa [Reaction:R-BTA-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - Bos taurus [Reaction:R-CFA-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - Canis familiaris [Reaction:R-RNO-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - Rattus norvegicus [Reaction:R-MMU-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - Mus musculus
output	[Complex:R-HSA-174095] Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol]
precedingEvent	[Reaction:R-HSA-174238] Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 - Homo sapiens [Reaction:R-HSA-170153] Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases - Homo sapiens
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174120
summation	[Summation:177325] Cyclin B is believed to be recognized by the APC/C:Cdc20 com...
updateTrackers	[UpdateTracker:9780950] Update Tracker - [Reaction:174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - v61:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9780950] Update Tracker - [Reaction:174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - v61:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-174048] APC/C:Cdc20 mediated degradation of Cyclin B
(precedingEvent)	[Reaction:R-HSA-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex