Reactome | Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex

Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex

Stable Identifier

R-HSA-174227

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Homo sapiens)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Homo sapiens)

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Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex', and 3 molecules of 'ubiquitin' are present. At the end of this reaction, 1 molecule of 'multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex' is present.

This reaction takes place in the 'cytosol' and is mediated by the 'ubiquitin-protein ligase activity' of 'Cdc20:Phospho-APC/C'.

Literature References

PubMed ID	Title	Journal	Year
11285280	Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint Peters, JM, Gannon, J, Geley, S, Kramer, E, Gieffers, C, Hunt, T	J Cell Biol	2001