Reactome | Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex

Schema > Reaction > Entries

Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex Show undefined attributes

catalystActivity	[CatalystActivity:10571651] ubiquitin-protein transferase activity of Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10571653
displayName	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
eventOf	[Pathway:R-DRE-174048] APC/C:Cdc20 mediated degradation of Cyclin B - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DRE-174157] Degradation of multiubiquitinated Cyclin B - Danio rerio
goBiologicalProcess	[GO_BiologicalProcess:7441] ubiquitin-dependent protein catabolic process
inferredFrom	[Reaction:R-HSA-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - Homo sapiens
input	[Complex:R-DRE-174095] Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] 4 × [DefinedSet:R-DRE-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
output	[Complex:R-DRE-174131] multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol]
precedingEvent	[Reaction:R-DRE-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-174227
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-174048] APC/C:Cdc20 mediated degradation of Cyclin B
(precedingEvent)	[BlackBoxEvent:R-DRE-174157] Degradation of multiubiquitinated Cyclin B
(inferredTo)	[Reaction:R-HSA-174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex

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