Ubiquitination of Securin by phospho-APC/C:Cdc20 complex

Stable Identifier
R-HSA-174144
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Securin is ubiquitinated by APC/C:Cdc20 (Hagting et al., 2002; Jin et al. 2008).

Literature References
PubMed ID Title Journal Year
18485873 Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex

Jin, L, Williamson, A, Banerjee, S, Philipp, I, Rape, M

Cell 2008
12070128 Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1

Hagting, A, Den Elzen, N, Vodermaier, HC, Waizenegger, IC, Peters, JM, Pines, J

J Cell Biol 2002
Participants
Participates
Event Information
Catalyst Activity

ubiquitin-protein transferase activity of CDC20:p-APC/C [cytosol]

Orthologous Events
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