Reactome | Alternative complement activation

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Alternative complement activation Show undefined attributes

authored	[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:173735] de Bono, B, 2006-02-16 13:02:56
dbId	173736
displayName	Alternative complement activation
edited	[InstanceEdit:1022120] Jupe, S, 2010-11-17
eventOf	[Pathway:R-HSA-166663] Initial triggering of complement - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:23217] complement activation, alternative pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-173739] Spontaneous hydrolysis of C3 thioester - Homo sapiens [Reaction:R-HSA-173740] Factor B binds to C3(H2O) - Homo sapiens [Reaction:R-HSA-173745] Factor D cleaves C3(H2O)-bound Factor B - Homo sapiens [Reaction:R-HSA-183130] C3(H2O):Factor Bb cleaves C3 to C3b and C3a - Homo sapiens [Reaction:R-HSA-981539] C3b binds to cell surface - Homo sapiens [Reaction:R-HSA-183126] Factor B binds to surface-associated C3b - Homo sapiens [Reaction:R-HSA-183122] Factor D cleaves C3b-bound Factor B - Homo sapiens [Reaction:R-HSA-173754] Properdin stabilizes C3b:Bb bound to cell surfaces - Homo sapiens [Reaction:R-HSA-174551] Formation of alternative pathway C5 convertase - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2013-09-23
literatureReference	[LiteratureReference:182557] Activation of the alternative complement pathway
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Alternative complement activation
orthologousEvent	[Pathway:R-GGA-173736] Alternative complement activation - Gallus gallus [Pathway:R-XTR-173736] Alternative complement activation - Xenopus tropicalis [Pathway:R-DRE-173736] Alternative complement activation - Danio rerio [Pathway:R-SSC-173736] Alternative complement activation - Sus scrofa [Pathway:R-BTA-173736] Alternative complement activation - Bos taurus [Pathway:R-CFA-173736] Alternative complement activation - Canis familiaris [Pathway:R-RNO-173736] Alternative complement activation - Rattus norvegicus [Pathway:R-MMU-173736] Alternative complement activation - Mus musculus
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
revised	[InstanceEdit:981538] Jupe, S, 2010-10-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-173736
summation	[Summation:174563] The proteins participating in alternative pathway activation...
updateTrackers	[UpdateTracker:9790020] Update Tracker - [Pathway:173736] Alternative complement activation - v35:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9786962] Update Tracker - [Pathway:173736] Alternative complement activation - v46:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9790020] Update Tracker - [Pathway:173736] Alternative complement activation - v35:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9786962] Update Tracker - [Pathway:173736] Alternative complement activation - v46:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-166663] Initial triggering of complement