Reactome | C3(H2O):Factor Bb cleaves C3 to C3b and C3a

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C3(H2O):Factor Bb cleaves C3 to C3b and C3a Show undefined attributes

authored	[InstanceEdit:173743] de Bono, B, 2006-02-16 13:19:05
catalystActivity	[CatalystActivity:183125] serine-type endopeptidase activity of C3(H2O):Bb [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:183129] de Bono, B, 2006-07-21 15:19:05
dbId	183130
displayName	C3(H2O):Factor Bb cleaves C3 to C3b and C3a
edited	[InstanceEdit:1022121] Jupe, S, 2010-11-17
eventOf	[Pathway:R-HSA-173736] Alternative complement activation - Homo sapiens
followingEvent	[Reaction:R-HSA-981539] C3b binds to cell surface - Homo sapiens
input	[Complex:R-HSA-166822] Complement factor 3 [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:173730] Molecular organization and function of the complement system
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	C3(H2O):Factor Bb cleaves C3 to C3b and C3a
orthologousEvent	[Reaction:R-XTR-183130] C3(H2O):Factor Bb cleaves C3 to C3b and C3a - Xenopus tropicalis [Reaction:R-DRE-183130] C3(H2O):Factor Bb cleaves C3 to C3b and C3a - Danio rerio [Reaction:R-SSC-183130] C3(H2O):Factor Bb cleaves C3 to C3b and C3a - Sus scrofa [Reaction:R-BTA-183130] C3(H2O):Factor Bb cleaves C3 to C3b and C3a - Bos taurus [Reaction:R-CFA-183130] C3(H2O):Factor Bb cleaves C3 to C3b and C3a - Canis familiaris [Reaction:R-MMU-183130] C3(H2O):Factor Bb cleaves C3 to C3b and C3a - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-166828] C3a [extracellular region] [Complex:R-HSA-166832] C3b [extracellular region]
precedingEvent	[Reaction:R-HSA-173745] Factor D cleaves C3(H2O)-bound Factor B - Homo sapiens
releaseDate	2006-08-02
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-183130
summation	[Summation:183127] C3(H2O):Factor Bb is a C3 convertase, sometimes referred to ...
updateTrackers	[UpdateTracker:9790139] Update Tracker - [Reaction:183130] C3(H2O):Factor Bb cleaves C3 to C3b and C3a - v35:[add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790139] Update Tracker - [Reaction:183130] C3(H2O):Factor Bb cleaves C3 to C3b and C3a - v35:[add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-173736] Alternative complement activation
(precedingEvent)	[Reaction:R-HSA-981539] C3b binds to cell surface

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