Reactome | Factor B binds to C3(H2O)

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Factor B binds to C3(H2O) Show undefined attributes

authored	[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:173742] de Bono, B, 2006-02-16 13:12:10
dbId	173740
displayName	Factor B binds to C3(H2O)
edited	[InstanceEdit:1022121] Jupe, S, 2010-11-17
eventOf	[Pathway:R-HSA-173736] Alternative complement activation - Homo sapiens
followingEvent	[Reaction:R-HSA-173745] Factor D cleaves C3(H2O)-bound Factor B - Homo sapiens
input	[Complex:R-HSA-182450] C3(H2O) [extracellular region] [EntityWithAccessionedSequence:R-HSA-173738] CFB(26-764) [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182527] Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Factor B binds to C3(H2O)
orthologousEvent	[Reaction:R-GGA-2132104] Complement factor B binds to the hydrolyzed form of C3 - Gallus gallus [Reaction:R-XTR-173740] Factor B binds to C3(H2O) - Xenopus tropicalis [Reaction:R-DRE-173740] Factor B binds to C3(H2O) - Danio rerio [Reaction:R-SSC-173740] Factor B binds to C3(H2O) - Sus scrofa [Reaction:R-BTA-173740] Factor B binds to C3(H2O) - Bos taurus [Reaction:R-CFA-173740] Factor B binds to C3(H2O) - Canis familiaris [Reaction:R-MMU-173740] Factor B binds to C3(H2O) - Mus musculus
output	[Complex:R-HSA-182529] C3(H2O):CFB [extracellular region]
precedingEvent	[Reaction:R-HSA-173739] Spontaneous hydrolysis of C3 thioester - Homo sapiens
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-173740
summation	[Summation:182528] Thioester bond hydrolysis causes conformational rearrangemen...
updateTrackers	[UpdateTracker:9790105] Update Tracker - [Reaction:173740] Factor B binds to C3(H2O) - v35:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790105] Update Tracker - [Reaction:173740] Factor B binds to C3(H2O) - v35:[modifyText]
(hasEvent)	[Pathway:R-HSA-173736] Alternative complement activation
(precedingEvent)	[Reaction:R-HSA-173745] Factor D cleaves C3(H2O)-bound Factor B