Reactome | Alternative complement activation

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Alternative complement activation Show undefined attributes

compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10443772
displayName	Alternative complement activation
eventOf	[Pathway:R-BTA-166663] Initial triggering of complement - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23217] complement activation, alternative pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-173739] Spontaneous hydrolysis of C3 thioester - Bos taurus [Reaction:R-BTA-173740] Factor B binds to C3(H2O) - Bos taurus [Reaction:R-BTA-173745] Factor D cleaves C3(H2O)-bound Factor B - Bos taurus [Reaction:R-BTA-183130] C3(H2O):Factor Bb cleaves C3 to C3b and C3a - Bos taurus [Reaction:R-BTA-981539] C3b binds to cell surface - Bos taurus [Reaction:R-BTA-183126] Factor B binds to surface-associated C3b - Bos taurus [Reaction:R-BTA-183122] Factor D cleaves C3b-bound Factor B - Bos taurus [Reaction:R-BTA-173754] Properdin stabilizes C3b:Bb bound to cell surfaces - Bos taurus [Reaction:R-BTA-174551] Formation of alternative pathway C5 convertase - Bos taurus
inferredFrom	[Pathway:R-HSA-173736] Alternative complement activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Alternative complement activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-173736
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-166663] Initial triggering of complement
(inferredTo)	[Pathway:R-HSA-173736] Alternative complement activation