Reactome | Activation of C1s

Schema > Reaction > Entries

Activation of C1s Show undefined attributes

authored	[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
catalystActivity	[CatalystActivity:173630] serine-type endopeptidase activity of Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643357] serine-type endopeptidase activity of Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:173632] de Bono, B, 2006-02-15 11:55:01
dbId	173631
displayName	Activation of C1s
eventOf	[Pathway:R-HSA-173623] Classical antibody-mediated complement activation - Homo sapiens
followingEvent	[Reaction:R-HSA-8852266] C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s - Homo sapiens [Reaction:R-HSA-166753] Conversion of C4 into C4a and C4b - Homo sapiens
input	[Complex:R-HSA-173619] Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182426] Physicochemical and functional characterization of the C1r subunit of the first complement component
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activation of C1s
orthologousEvent	[Reaction:R-GGA-2132065] C1r activates C1s component within C1 complement complex - Gallus gallus [Reaction:R-GGA-173631] Activation of C1s - Gallus gallus [Reaction:R-SSC-173631] Activation of C1s - Sus scrofa [Reaction:R-BTA-173631] Activation of C1s - Bos taurus [Reaction:R-CFA-173631] Activation of C1s - Canis familiaris [Reaction:R-RNO-173631] Activation of C1s - Rattus norvegicus [Reaction:R-MMU-173631] Activation of C1s - Mus musculus
output	[Complex:R-HSA-173618] Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane]
precedingEvent	[Reaction:R-HSA-173626] Activation of C1r - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-173631
summation	[Summation:182422] In this irreversible reaction, the activated C1r subunit of ...
updateTrackers	[UpdateTracker:9789513] Update Tracker - [Reaction:173631] Activation of C1s - v38:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789513] Update Tracker - [Reaction:173631] Activation of C1s - v38:[modifyText]
(precedingEvent)	[Reaction:R-HSA-8852266] C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s [Reaction:R-HSA-166753] Conversion of C4 into C4a and C4b
(hasEvent)	[Pathway:R-HSA-173623] Classical antibody-mediated complement activation