Reactome | Activation of C1r

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Activation of C1r Show undefined attributes

authored	[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
catalystActivity	[CatalystActivity:173628] serine-type endopeptidase activity of Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643521] serine-type endopeptidase activity of Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane] The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:173625] de Bono, B, 2006-02-15 11:47:49
dbId	173626
displayName	Activation of C1r
eventOf	[Pathway:R-HSA-173623] Classical antibody-mediated complement activation - Homo sapiens
followingEvent	[Reaction:R-HSA-173631] Activation of C1s - Homo sapiens
input	[Complex:R-HSA-173582] Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182425] Activation of C1r by proteolytic cleavage
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activation of C1r
orthologousEvent	[BlackBoxEvent:R-GGA-2132122] Activation of C1r within the C1complement complex - Gallus gallus [Reaction:R-GGA-173626] Activation of C1r - Gallus gallus [Reaction:R-SSC-173626] Activation of C1r - Sus scrofa [Reaction:R-BTA-173626] Activation of C1r - Bos taurus [Reaction:R-CFA-173626] Activation of C1r - Canis familiaris [Reaction:R-RNO-173626] Activation of C1r - Rattus norvegicus [Reaction:R-MMU-173626] Activation of C1r - Mus musculus
output	[Complex:R-HSA-173619] Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane]
regulatedBy	[PositiveRegulation:R-HSA-977428] Positive regulation by 'C-reactive protein pentamer:phosphocholine:C1Q [extracellular region]'
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-173626
summation	[Summation:174559] C1 activation requires interaction with two separate Fc doma...
updateTrackers	[UpdateTracker:9790115] Update Tracker - [Reaction:173626] Activation of C1r - v35:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9790115] Update Tracker - [Reaction:173626] Activation of C1r - v35:[addRegulator]
(hasEvent)	[Pathway:R-HSA-173623] Classical antibody-mediated complement activation
(precedingEvent)	[Reaction:R-HSA-173631] Activation of C1s