Reactome | Classical antibody-mediated complement activation

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Classical antibody-mediated complement activation Show undefined attributes

authored	[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:173624] de Bono, B, 2006-02-15 11:42:00
dbId	173623
displayName	Classical antibody-mediated complement activation
eventOf	[Pathway:R-HSA-166786] Creation of C4 and C2 activators - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:23218] complement activation, classical pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-173626] Activation of C1r - Homo sapiens [Reaction:R-HSA-173631] Activation of C1s - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2013-06-30
literatureReference	[LiteratureReference:173694] X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement. [LiteratureReference:174546] Structural and functional studies on C1r and C1s: new insights into the mechanisms involved in C1 activity and assembly
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Classical antibody-mediated complement activation
orthologousEvent	[Pathway:R-GGA-2132286] Classical antibody-mediated complement activation - Gallus gallus [Pathway:R-GGA-173623] Classical antibody-mediated complement activation - Gallus gallus [Pathway:R-SSC-173623] Classical antibody-mediated complement activation - Sus scrofa [Pathway:R-BTA-173623] Classical antibody-mediated complement activation - Bos taurus [Pathway:R-CFA-173623] Classical antibody-mediated complement activation - Canis familiaris [Pathway:R-RNO-173623] Classical antibody-mediated complement activation - Rattus norvegicus [Pathway:R-MMU-173623] Classical antibody-mediated complement activation - Mus musculus
releaseDate	2006-08-02
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-173623
summation	[Summation:174558] C1, the first component of complement is a complex containin...
updateTrackers	[UpdateTracker:9789257] Update Tracker - [Pathway:173623] Classical antibody-mediated complement activation - v38:[updateContainedRLE] [UpdateTracker:9787326] Update Tracker - [Pathway:173623] Classical antibody-mediated complement activation - v45:[modifyText] [UpdateTracker:9790089] Update Tracker - [Pathway:173623] Classical antibody-mediated complement activation - v35:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9789257] Update Tracker - [Pathway:173623] Classical antibody-mediated complement activation - v38:[updateContainedRLE] [UpdateTracker:9787326] Update Tracker - [Pathway:173623] Classical antibody-mediated complement activation - v45:[modifyText] [UpdateTracker:9790089] Update Tracker - [Pathway:173623] Classical antibody-mediated complement activation - v35:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-166786] Creation of C4 and C2 activators