Activation of C1s

Stable Identifier
R-HSA-173631
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Activation of C1s
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In this irreversible reaction, the activated C1r subunit of the C1:antibody:antigen complex cleaves the C1s subunit of the complex, activating it in turn (Ziccardi and Cooper 1976). The resulting complex is a C4 activator.

Literature References
PubMed ID Title Journal Year
814163 Physicochemical and functional characterization of the C1r subunit of the first complement component

Cooper, NR, Ziccardi, RJ

J Immunol 1976
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane]

Physical Entity
Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
C1r activates C1s component within C1 complement complex (Gallus gallus)
Activation of C1s (Bos taurus)
Activation of C1s (Canis familiaris)
Activation of C1s (Danio rerio)
Activation of C1s (Gallus gallus)
Activation of C1s (Mus musculus)
Activation of C1s (Rattus norvegicus)
Activation of C1s (Sus scrofa)
Activation of C1s (Xenopus tropicalis)
Authored
de Bono, B  (2004-08-04)
Reviewed
D'Eustachio, P  (2006-07-04)
Created
de Bono, B  (2006-02-15)
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