Activation of C1s

Stable Identifier
R-HSA-173631
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In this irreversible reaction, the activated C1r subunit of the C1:antibody:antigen complex cleaves the C1s subunit of the complex, activating it in turn (Ziccardi and Cooper 1976). The resulting complex is a C4 activator.

Literature References
PubMed ID Title Journal Year
814163 Physicochemical and functional characterization of the C1r subunit of the first complement component

Ziccardi, RJ, Cooper, NR

J Immunol 1976
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created