Activation of C1s

Stable Identifier
R-HSA-173631
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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In this irreversible reaction, the activated C1r subunit of the C1:antibody:antigen complex cleaves the C1s subunit of the complex, activating it in turn (Ziccardi and Cooper 1976). The resulting complex is a C4 activator.
Literature References
PubMed ID Title Journal Year
814163 Physicochemical and functional characterization of the C1r subunit of the first complement component

Cooper, NR, Ziccardi, RJ

J Immunol 1976
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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