Reactome | Activation of C1r

Schema > Reaction > Entries

Activation of C1r Show undefined attributes

catalystActivity	[CatalystActivity:10346269] serine-type endopeptidase activity of Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10346281
displayName	Activation of C1r
eventOf	[Pathway:R-BTA-173623] Classical antibody-mediated complement activation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-173631] Activation of C1s - Bos taurus
inferredFrom	[Reaction:R-HSA-173626] Activation of C1r - Homo sapiens
input	[Complex:R-BTA-173582] Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of C1r
output	[Complex:R-BTA-173619] Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane]
regulatedBy	[PositiveRegulation:10346282] Positive regulation by 'C-reactive protein pentamer:phosphocholine:C1Q [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-173626
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-173623] Classical antibody-mediated complement activation
(precedingEvent)	[Reaction:R-BTA-173631] Activation of C1s
(inferredTo)	[Reaction:R-HSA-173626] Activation of C1r