Reactome | Classical antibody-mediated complement activation

Schema > Pathway > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556553
displayName	Classical antibody-mediated complement activation
eventOf	[Pathway:R-SSC-166786] Creation of C4 and C2 activators - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23218] complement activation, classical pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-173626] Activation of C1r - Sus scrofa [Reaction:R-SSC-173631] Activation of C1s - Sus scrofa
inferredFrom	[Pathway:R-HSA-173623] Classical antibody-mediated complement activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Classical antibody-mediated complement activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-173623
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-166786] Creation of C4 and C2 activators
(inferredTo)	[Pathway:R-HSA-173623] Classical antibody-mediated complement activation

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