Reactome | C3G stimulates nucleotide exchange on Rap1

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:182092] guanyl-nucleotide exchange factor activity of Active Trk receptor:Frs3:Crk:C3G [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:182105] Jassal, Bijay, 2006-07-06
dbId	182053
displayName	C3G stimulates nucleotide exchange on Rap1
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-RNO-182015] Rap1-GDP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182068] Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	C3G stimulates nucleotide exchange on Rap1
orthologousEvent	[Reaction:R-HSA-170979] (Frs2)C3G stimulates nucleotide exchange on Rap1 - Homo sapiens
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-RNO-182080] Rap1-GTP [cytosol]
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-182053
summation	[Summation:187780] Rap1 is a small G protein, necessary for prolonged ERK activ...

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